Low Dose Naltrexone (LDN): A Promising Option for Chronic Inflammation and Autoimmune Conditions

As a nurse practitioner, my goal is to help patients understand emerging treatment options that may improve quality of life—especially when conventional therapies have not fully addressed chronic symptoms. One medication gaining increased attention in integrative and functional medicine is Low Dose Naltrexone (LDN).

LDN is not a miracle drug, but for some patients, it can be a helpful tool in managing chronic inflammation, autoimmune conditions, and persistent pain.

Let’s walk through what it is, how it works, and whether it might be an appropriate option.

What Is Low Dose Naltrexone?

Naltrexone is an FDA-approved medication traditionally used at higher doses (50 mg) to treat opioid and alcohol dependence. However, at much lower doses, it appears to have a very different effect on the body.

This lower dosing approach is known as Low Dose Naltrexone (LDN) and is used off-label for a variety of chronic conditions.

How Does LDN Work in the Body?

At low doses, naltrexone briefly blocks opioid receptors in the brain. This temporary blockade signals the body to increase production of natural endorphins, which play a role in:

• Pain regulation

• Weight Loss

• Immune system modulation

• Inflammation control

LDN may also help reduce overactive immune responses, which is particularly relevant in autoimmune and inflammatory disorders.

Conditions Where LDN May Be Helpful

LDN is most often considered for patients with chronic, inflammatory, or immune-related conditions, including:

Autoimmune Conditions

• Hashimoto’s thyroiditis, Multiple sclerosis (MS), Rheumatoid arthritis, Lupus, Crohn’s disease

Chronic Pain & Fatigue Disorder

• Fibromyalgia, Chronic fatigue syndrome, Complex regional pain syndrome, Persistent musculoskeletal pain

Neurological & Inflammatory Conditions

• Long COVID, Migraines, Endometriosis, Irritable bowel syndrome (IBS)

Potential Benefits Patients Report

• Reduced chronic pain

• Improved energy and stamina

• Better sleep quality

• Fewer autoimmune flare-ups

• Reduced brain fog

• Improved overall sense of well-being

One advantage of LDN is that it is non-sedating, non-addictive, and generally well tolerated.

Possible Side Effects

Most patients tolerate LDN well. When side effects occur, they are usually mild and temporary, such as: vivid dreams or sleep changes, mild headaches, nausea, temporary fatigue. 

Important Safety Considerations

LDN is not appropriate for everyone. It should not be taken with opioid medications. It requires a prescription and medical oversight. It may take 4–12 weeks to notice benefits

A thoughtful discussion with your healthcare provider is the best way to determine if LDN fits your personal health plan.

How We Can Help

At Sandhill Direct Health, we closely monitor patient response and adjust treatment plans based on individual needs. We prioritize time, personalization, and root-cause care. 

Our goal is to treat the whole person—not just symptoms.

If you are curious whether LDN might be appropriate for you, we will be happy to discuss it during your visit.